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Picture of Zebra finch B.A. Schlinger Laboratory
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Picture of Manakin  
image of bird

Lab Members
Anahid Mirzatoni
Amnon Katz
Luke Remage-Healey
Barney Schlinger
Rory Spence
   
Alumni
Virginie Canoine
Lainy Day
Leonida Fusani
Sarah London
Scott Peterson
Colin Saldanha
Doug Schultz

Kiran Soma

Helen Tam

   

Sarah E. London

Currently: Postdoctoral Researcher, University of Illinois Urbana-Champagne

Formerly: Graduate student, Neuroscience IDP Program, Laboratory of Neuroendocrinology, UCLA

Principle Research Interests:
In the zebra finch, estrogen is a masculinizing steroid for the sexually dimorphic song system. Contrary to traditional theories, the gonads are probably not the source of these estrogens. I am interested in testing the idea that the zebra finch brain is itself capable of synthesizing masculinizing steroids, and that the male brain has a greater capacity than the female brain. Therefore, I am mapping the expression levels and patterns of three steroidogenic enzymes: side chain cleavage (CYP11A1), 3b-hydroxysteroid dehydrogenase (3b-HSD), and 17a hydroxylase/17,20 lyase (CYP17) in developing and adult brains. Neurosteroidogenesis. Sex differences. Neural development. Action of sex steroids in brain.

E-mail: slondon@ucla.edu

Education:
B.A. Middlebury College, Middlebury, VT

Selected Publications:
Saldanha, CJ, Schultz, JD, London, SE, Schlinger, BA. (2000). Telencephalic aromatase but not a song circuit in a sub-oscine passerine, the golden-collared manakin (Manacus vitellinus). Brain Behavior and Evolution. 2000. 56(1) 29-37
http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=BBE&action=render&rendertype=abstract&uid=BBE.bbe56029

Schlinger BA, Soma KK, London S.E. (2001). Neurosteroids and brain sexual differentiation. Trends Neuroscience. 24(8):429-31.
http://reviews.bmn.com/browse/areas/record?uid=TINS.etd00816_01662236_v0024i08_00001855

Schlinger, B.A., K.K. Soma and S.E. London. 2002. Integrating Steroid Synthesis with Steroid Action: Multiple Mechanisms in Birds. Proc.23rd International Ornithological Congress, Beijing, China, August.

London, S.E., J. Boulter and B.A. Schlinger. 2003. Cloning of the androgen synthetic enzyme CYP17 in the Zebra Finch: A study of its neural expression throughout development.   Journal of Comparative Neurology 467: 496-508.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14624484&dopt=Books

Teramitsu I, Kudo LC, London SE, Geschwind DH, White SA.  (2004). Parallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction.  J Neuroscience.  24:3152-63.
 

Selected Abstracts:
Saldanha, CJ, London, SE, Sanford, K, Clayton, NS & Schlinger, BA. (1998). Androgen metabolism in the juvenile oscine forebrain: a cross-species comparison at neural loci implicated in learning and memory. Society for Neuroscience Abstracts. 24(1):699.

Schlinger, BA, London, SE, Schultz, JD, Saldanha, CJ. (1998). Aromatase in the brain of a sub-oscine bird. Society for Neuroscience Abstracts. 24(1):698.

London SE, Schlinger BA. (2002). CYP17 Expression in Adult and Developing Zebra Finch Brain. Society for Behavioral Neuroendocrinology Abstracts. Hormones and Behavior. 40(4):478.

London SE, Schlinger BA. (2002). CYP17 Expression in Zebra Finch Brain. Society for Neuroscience Abstracts. No. 781.3.
 
London SE and Schlinger BA. (2003). Evidence for Steroid Synthesis in Songbird Brain: Cloning and Expression of 3b-HSD.  Society for Behavioral Neuroendocrinology Abstracts. Hormones and Behavior. 44(1):62.

London SE and Schlinger BA. (2003). Evidence for Neurosteroidogenesis in a Songbird: Cloning and Expression of 3b-HSD.  Society for Neuroscience Abstracts. No. 94.16.


Affiliations:
Society for Neuroscience
Society for Behavioral Neuroendocrinology

 
 

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