Sarah E. London
Currently: Postdoctoral Researcher, University of Illinois Urbana-Champagne
Formerly: Graduate student, Neuroscience IDP Program, Laboratory
of Neuroendocrinology, UCLA
Principle Research Interests:
In the zebra finch, estrogen is a masculinizing steroid for the
sexually dimorphic song system. Contrary to traditional theories, the
gonads are probably not the source of these estrogens. I am interested
in testing the idea that the zebra finch brain is itself capable of
synthesizing masculinizing steroids, and that the male brain has a
greater capacity than the female brain. Therefore, I am mapping the
expression levels and patterns of three steroidogenic enzymes: side
chain cleavage (CYP11A1), 3b-hydroxysteroid dehydrogenase (3b-HSD), and
17a hydroxylase/17,20 lyase (CYP17) in developing and adult brains.
Neurosteroidogenesis. Sex differences. Neural development. Action of
sex steroids in brain.
E-mail: slondon@ucla.edu
Education:
B.A. Middlebury College, Middlebury, VT
Selected Publications:
Saldanha, CJ, Schultz, JD, London, SE, Schlinger, BA.
(2000). Telencephalic aromatase but not a song circuit in a sub-oscine
passerine, the golden-collared manakin (Manacus vitellinus). Brain
Behavior and Evolution. 2000. 56(1) 29-37
http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=BBE&action=render&rendertype=abstract&uid=BBE.bbe56029
Schlinger BA, Soma KK, London S.E. (2001). Neurosteroids
and brain sexual differentiation. Trends Neuroscience. 24(8):429-31.
http://reviews.bmn.com/browse/areas/record?uid=TINS.etd00816_01662236_v0024i08_00001855
Schlinger,
B.A., K.K. Soma and S.E. London.
2002. Integrating Steroid Synthesis with Steroid Action: Multiple
Mechanisms in
Birds. Proc.23rd International Ornithological Congress, Beijing, China,
August.
London,
S.E., J. Boulter and B.A. Schlinger. 2003. Cloning of the androgen
synthetic
enzyme CYP17 in the Zebra Finch: A study of its neural expression
throughout
development. Journal of
Comparative Neurology 467:
496-508.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14624484&dopt=Books
Teramitsu I, Kudo LC, London SE, Geschwind DH, White
SA.
(2004). Parallel FoxP1 and FoxP2 Expression in Songbird
and
Human Brain Predicts Functional Interaction. J
Neuroscience. 24:3152-63.
Selected Abstracts:
Saldanha, CJ, London, SE, Sanford, K, Clayton, NS &
Schlinger, BA. (1998). Androgen metabolism in the juvenile oscine
forebrain: a cross-species comparison at neural loci implicated in
learning and memory. Society for Neuroscience Abstracts. 24(1):699.
Schlinger, BA, London, SE, Schultz, JD, Saldanha, CJ. (1998). Aromatase
in the brain of a sub-oscine bird. Society for Neuroscience
Abstracts. 24(1):698.
London SE, Schlinger BA. (2002). CYP17 Expression in
Adult and Developing Zebra Finch Brain. Society for Behavioral
Neuroendocrinology Abstracts. Hormones and Behavior. 40(4):478.
London SE, Schlinger BA. (2002). CYP17 Expression in
Zebra Finch Brain. Society for Neuroscience Abstracts. No. 781.3.
London SE and Schlinger BA. (2003). Evidence for
Steroid Synthesis in
Songbird Brain: Cloning and Expression of 3b-HSD. Society for
Behavioral Neuroendocrinology Abstracts. Hormones and Behavior.
44(1):62.
London SE and Schlinger BA. (2003). Evidence
for Neurosteroidogenesis in a Songbird: Cloning and Expression of
3b-HSD. Society for Neuroscience Abstracts. No. 94.16.
Affiliations:
Society for Neuroscience
Society for Behavioral Neuroendocrinology
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