Research Interests

• Contractile proteins associated with neuromuscular and cardiovascular disorders.

• Disease pathogenesis of neuromuscular and cardiovascular disorders.

Education
Postdoctorate	Department of Biomedical Sciences, University of Leeds, United Kingdom, Advisor: Michelle Peckham, Ph.D Research projects: Effect of familial Hypertrophic Cardiomyopathy mutations on ß-Cardiac myosin. The effects of targeting the titin kinase gene upon myofibrillogenesis.	1998-2001
Ph.D.	Royal Free Hospital and School of Medicine London, United Kingdom Dissertation Title: Modelling gene therapy for haemophilia	1993-1998
B.S.	Department of Genetics, University of Sheffield, United Kingdom	1992

Publications

Miller G, Heighway J and R.H. Crosbie "The Identification and Characterization of Microspan: a Novel Isoform of Sarcospan" Under review.

Miller G, Lipman K, Wang E & RH Crosbie "Structural Determinants Mediating Sarcospan-Sarcoglycan Interactions." In preparation.

Miller G, Musa H, Gautel M and Peckham M. (2003)."A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis." J. Cell Sci., 116, 4811-4819.

Miller G, Maycock J, White E, Peckham M and Calaghan S. (2003) "Heterologous expression of wild type and mutant b-cardiac myosin changes the contraction kinetics of cultured myotubes." J. Physiol 548.1, 167-174.

Yi C, Bekker JM, Miller G, Hill K and Crosbie RH. (2003) "Specific and potent RNA interference in terminally differentiated myotubes. J. Biol. Chem, 278, 934-939.

Peckham M, Miller G, Wells C, Zicha D and Dunn G. (2001). Specific changes to the mechanism of cell locomotion induced by overexpression of ß-actin. J. Cell Sci., 114, 1367-1377. See also http://www.nature.com/nsu/010329/010329-10.html

Miller G, Colegrave M and Peckham M. (2000). N232S, G741R & D778G ß-cardiac myosin mutants implicated in familial hypertrophic cardiomyopathy, do not disrupt myofibrillar organisation in cultured myotubes. FEBS Letters, 486, 325-327.

Miller G, Steinbrecher RA, Murdock PJ, Tuddenham EGD, Lee CA, Pasi KJ and Goldspink G. (1995). Expression of Factor VII by Muscle Cells in vitro and in vivo following Direct Gene Transfer: Modelling Gene Therapy for Haemophilia. Gene Therapy; 2:736-742.

Quote of the Month

Education is an admirable thing, but it is well to remember from time to time that nothing that is worth knowing can be taught. ---Oscar Wilde (1854 - 1900)