Home
Lab Members
Research Areas
Publications
Antibodies
Collaborators
Links
Research Alumni
Contact Info

Assistant Professor
Department of Physiological Science, Molecular Biology Institute, UCLA
Office Tel: 310-794-2103
Lab Tel: 310-445-2107
Fax: 310-206-3987
Email: rcrosbie@physci.ucla.edu

Education
Postdoctorate
  • Department of Physiology & Biophysics
    University of Iowa, Howard Hughes Medical Institute
    Advisor: Kevin P. Campbell, Ph.D. Professor & Chair of Physiology and Investigator of the Howard Hughes Medical Institute
1995-1999
Ph.D.
  • Department of Chemistry & Biochemistry
    University of California at Los Angeles
    Advisor: Emil Reisler, Ph.D. Professor of Biochemistry
    Dissertation Title: Structural Determinants of Actin Function and its Effects on the Components of the Motile Apparatus
1990-1994
B.S.
  • Department of Biochemistry
    Texas A&M University
    Advisor: Gary E. Gallick, Ph.D., Professor of Cancer Biology, M.D. Anderson Cancer Hospital and Research Institute
1984-1989
Awards & Honors
  • Dean's Marshal Award
    College of Letters and Science, UCLA
2001
  • Faculty Career Development Award
    UCLA Council on Research
2000
  • Excellence in Postdoctorate Research Award
    University of Iowa College of Medicine
1998
  • Young Scientist Travel Award
    American Society of Biochemistry and Molecular Biology
1997
  • Excellence in Postdoctorate Research Award
    University of Iowa College of Medicine
1997
  • Robert G. Sampson Named Neuromuscular Disease Research Fellowship
    Muscular Dystrophy Association
1996-98
  • UCLA Award for Excellence in Graduate Research
    Department of Chemistry & Biochemistry
1992
  • UCLA Distinguished Teaching Assistant Award
    Department of Chemistry & Biochemistry
1992
  • Excellence in Undergraduate Research Award
    Texas A&M University
1989
  • Distinguished Biochemistry Undergraduate Student
    Texas A&M University
1988
Professional Experience
Editorial Board Member
• Human Molecular Genetics, 2004-present
Ad Hoc Manuscript Reviewer
  • Nature Med.
  • J. Cell Biol.
  • J. Biol. Chem.
  • J. Clin. Chem.
  • Naturwissen.
  • Muscle and Nerve
  • Mol. Biol. Cell
  • Biochem.
  • Histochem. J.
  • Mol. Biol. Cell
  • Hum. Mol. Genet.
  • J. Neuropath. & Exp. Neurol.
Ad Hoc Grant Reviewer
• The Muscular Dystrophy Campaign, Cambridge
• NIH-NIAMS Study Section
Patents
“Sarcospan-Deficient Mouse as a Model for Clinical Disorders Associated with Sarcospan Mutations” U.S. Patent No. 6,207,878 B1. Inventors: Kevin P. Campbell, Connie S. Lebakken, Rachelle H. Crosbie, and Roger Williamson. Date of Patent: March 27, 2001.
Courses Taught
• Cell Structure, Signaling, and Development CM267, graduate level course, module entitled “Muscle Cell Structure & Function”
• Muscle Physiology 111B, upper level undergraduate course
• Muscle Physiology 270B & 298, graduate level seminar course
• Current Topics in Research 195H, undergraduate level seminar course
• MCIP IDP Graduate Student Tutorial 297
Publications
Yi, C.E., Bekker, J.M, Miller, G., Hill, K.L. and R.H. Crosbie (2003) "Specific and Potent RNA Interference in Terminally Differentiated Myotubes." J. Biol. Chem. 278: 934-939.

Crosbie, R. H., Barresi, R., and K.P. Campbell (2002) "Loss of Sarcolemma nNOS in Sarcoglycan-Deficient Muscle." FASEB J. 16: 1786-1791.

Crosbie, R.H., Dovico, S.A., Cohn, R.D., Flanagan, J.D., Chamberlain, J.S., Ownby, C.L., and K.P. Campbell (2002) "Characterization of Aquaporin-4 in Muscle and Muscular Dystrophy." FASEB J. 16: 943-949.

Crosbie, R.H. (2001) “News and Views: NO Vascular Control in Duchenne Muscular Dystrophy” Nature Med. 7: 27-29.

Crawford, G.E., Faulkner, J.A., Crosbie, R.H., Campbell, K.P., Froehner, S.C., and J.S. Chamberlain (2000) "Assembly of the Dystrophin Associated Protein Complex Does Not Require the Dystrophin C-terminal Domain" J. Cell Biol. 150: 1411-1422.

Crosbie, R.H., Lim, L.E., Moore, S.A., Hirano, M., Hays, A.P., Maybaum, S.W., Collin, H., Stolle, C.A., Fardeau, M., Tomé, F.M.S., and Campbell, K.P. (2000) “Molecular and Genetic Characterization of Sarcospan: Insights into Sarcoglycan-Sarcospan Interactions” Hum. Mol. Gen. 9: 2019-2027.

Holt, K.H., Crosbie, R.H., Venzke, D.P., and Campbell, K.P. (2000) “Biosynthesis of Dystroglycan: Processing of a Precursor Propeptide” FEBS Lett. 468: 79-83.

Crosbie, R.H., Lebakken, C.S., K.H. Holt, Venzke, D.P., Straub, V., Lee, J.C., Grady, R.M., Chamberlain, J.S., Sanes, J.R., and Campbell, K.P. (1999) “Membrane Targeting and Stabilization of Sarcospan is Mediated by the Sarcoglycan Subcomplex.” J. Cell Biol. 145:153-165.

Duclos, F., Straub, V., Moore, S.A, Venzke, D.P., Hrstka, R.F., Crosbie, R.H., Durbeej, M., Lebakken, C.S., Ettinger, A.J., van der Meulen, J., Holt, K.H., Lim, L.E., Sanes, J.R., Davidson, B.L., Faulkner, J.A., Williamson, R., and Campbell, K.P. (1998) “Progressive Muscular Dystrophy in ?-Sarcoglycan Deficient Mice” J. Cell Biol. 142, 1461-1471.

Crosbie, R.H., Yamada, H., Venzke, D.P., Lisanti, M.P. and Campbell, K.P. (1998) “Caveolin-3 is Not an Integral Component of the Dystrophin-Glycoprotein Complex” FEBS Lett. 427, 279-282.

Crosbie, R.H., Straub, V., Lee, J.C., Yun, H.Y., Rafael, J.A, Chamberlain, J.S., Dawson, V.L., Dawson, T.M. and Campbell, K.P. (1998) “mdx Muscle Pathology is Independent of nNOS Perturbation” Hum. Mol. Gen. 7, 823-829.

Crosbie, R.H., Heighway, J., Venzke, D.P., Lee, J.C. and Campbell, K.P. (1997) “Sarcospan: The 25kDa Transmembrane Component of the Dystrophin-Glycoprotein Complex” J. Biol. Chem. 272, 31221-31224.

Campbell, K.P. and Crosbie, R.H. (1996) “News and Views: Utrophin to the Rescue” Nature 384, 308-309. (Review Article)

Crosbie, R.H., Chalovich, J.M., and Reisler, E. (1995) “Flexation of Caldesmon: Effect of Conformation on the Properties of Caldesmon” J. Muscle Res. Cell Motil. 16, 509-518.

Crosbie, R.H. (1995) “Structural Determinants of Actin Function and its Effects on the Components of the Motile Apparatus” Ph.D. Dissertation, University of California at Los Angeles.

Crosbie, R.H., Miller, C., Cheung, P., Goodnight, T., Muhlrad, A. and Reisler, E. (1994) “Structural Connectivity in Actin: Effect of C-terminal Modifications on the Properties of Actin” Biophys. J. 67, 1964-1967.

Crosbie, R.H., Miller, C., Rubenstein, P.A., Chalovich, J.M. and Reisler, E. (1994) “Caldesmon, N-terminal Yeast Actin Mutants, and the Regulation of Actomyosin Interactions” Biochemistry 33, 3210-3216.

Crosbie, R.H., Chalovich, J.M. and Reisler, E. (1992) “The Interaction of Caldesmon and Myosin Subfragment-1 with the C-terminus of Actin” Biochem. Biophys. Res. Commun. 184, 239-245.

Crosbie, R.H., Adams, S., Chalovich, J.M. and Reisler, E. (1991) “The Interaction of Caldesmon with the COOH-Terminus of Actin” J. Biol. Chem. 266, 20001-20006.

Webmaster
The Crosbie Lab, UCLA
Designed By: Jessica Wood