email: fgomezpi@ucla.edu
phone: 310-206-9693
office: 1814 LS
homepage: http://www.physci.ucla.edu/research/GomezPinilla/
research interests: Mechanisms of Neural Repair
Research Interests
Role of Trophic Factors on Activity-dependent Plasticity We are interested on the mechanisms by which environmental factors affect neuronal health. We have found that trophic factors endogenous to the brain and spinal cord can be induced by the practice of select behaviors. We have recently reported that physical activity, learning, and nutritional factors control neurotrophins in the brain. These findings opened the exciting possibility that regulation of trophic factors by behavior can be a pivotal mechanism by which specific experiences can impact the structure and function of the CNS. It may account for the improvement of CNS function after trauma provided by rehabilitative therapies. On the contrary, it may explain the decay in function in aging or degenerative diseases following a lack of stimulation. These two avenues provide direction for my research program: 1) How trophic factors induced by activity can help functional recovery following brain and spinal cord trauma. We are using several exercise models to boost the production of trophic factors in the brain and spinal cord. Our goal is to provide critical information to guide the design of behavioral therapies for the reduction of the severity of insult or disease, and to increase CNS function. 2) We are evaluating the effects of lifestyle on trophic factor production, with resulting effects on circuit remodeling, synaptic function, and cognition. We believe that changes in trophic factor as a result of select experiences can affect neuronal health with profound consequences for cognitive function.
Selected Publications
Molteni R, Zheng JQ, Ying Z, Gomez-Pinilla F, Twiss JL.. 2004. Voluntary exercise increases axonal regeneration from sensory neurons Proc Natl Acad Sci U S A 101(22) :8473-8 .
Hutchinson KJ, Gomez-Pinilla F, Crowe MJ, Ying Z, Basso DM.. 2004. Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats Brain 127(Pt 6): 1403-14 .
Griesbach GS, Hovda DA, Molteni R, Wu A, Gomez-Pinilla F.. 2004. Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function Neuroscience 125(1) 129-39 .
Vaynman S, Ying Z, Gomez-Pinilla F.. 2004. Exercise induces BDNF and synapsin I to specific hippocampal subfields J Neurosci Res 76(3): 356-62 .
Wu A, Ying Z, Gomez-Pinilla F.. 2004. The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition Eur J Neurosci 19(7): 1699-707 .
Molteni R, Wu A, Vaynman S, Ying Z, Barnard RJ, Gomez-Pinilla F.. 2004. Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor Neuroscience 123(2) 429-40 .
Vaynman S, Ying Z, Gomez-Pinilla F.. 2003. Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity Neuroscience 122(3) 647-57 .
Ying Z, Roy RR, Edgerton VR, Gomez-Pinilla F.. 2003. Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord Brain Res 987(1) 93-9 .
Li, H.H., Neufeld, E.F., Cai, Y., Zhao, H-Z., and Gómez-Pinilla, F. 2002. Attenuated plasticity in neurons and astrocytes in the mouse model of Sanfilippo Syndrome Type B J. Neurosci. Res 69(1) 30-38 .
Molteni, R., Barnard, J.R., Ying, Z., Roberts, C.K., and Gómez-Pinilla, F.. 2002. A high-fat, refined-sugar diet reduces BDNF, neuronal plasticity, and cognitive function Neuroscience 112(4) 803-814 .